Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1997 1
1999 1
2000 1
2001 1
2002 2
2005 1
2006 4
2007 4
2008 5
2009 4
2010 7
2011 6
2012 4
2013 1
2014 3
2015 3
2016 3
2017 4
2018 1
2019 3
2020 2
2021 5
2022 2
2023 2
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

66 results

Results by year

Filters applied: . Clear all
Page 1
Polymorphism of human cytochrome P450 enzymes and its clinical impact.
Zhou SF, Liu JP, Chowbay B. Zhou SF, et al. Drug Metab Rev. 2009;41(2):89-295. doi: 10.1080/03602530902843483. Drug Metab Rev. 2009. PMID: 19514967 Review.
Approximately 5-14% of Caucasians, 0-5% Africans, and 0-1% of Asians lack CYP2D6 activity, and these individuals are known as poor metabolizers. CYP2C9 is another clinically significant enzyme that demonstrates multiple genetic variants with a potentially fun …
Approximately 5-14% of Caucasians, 0-5% Africans, and 0-1% of Asians lack CYP2D6 activity, and these individuals are known as poor me …
Trends in Tramadol: Pharmacology, Metabolism, and Misuse.
Miotto K, Cho AK, Khalil MA, Blanco K, Sasaki JD, Rawson R. Miotto K, et al. Anesth Analg. 2017 Jan;124(1):44-51. doi: 10.1213/ANE.0000000000001683. Anesth Analg. 2017. PMID: 27861439 Review.
Tramadol is a unique analgesic medication, available in variety of formulations, with both monoaminergic reuptake inhibitory and opioid receptor agonist activity increasingly prescribed worldwide as an alternative for high-affinity opioid medication in the treatment of acute and …
Tramadol is a unique analgesic medication, available in variety of formulations, with both monoaminergic reuptake inhibitory and opioid rece …
Pharmacogenetics-Guided Advances in Antipsychotic Treatment.
Islam F, Men X, Yoshida K, Zai CC, Müller DJ. Islam F, et al. Clin Pharmacol Ther. 2021 Sep;110(3):582-588. doi: 10.1002/cpt.2339. Epub 2021 Aug 18. Clin Pharmacol Ther. 2021. PMID: 34129738 Review.
Most robust findings from candidate gene and genomewide association studies were reported for associations between polymorphisms in CYP2D6 and exposure and response to specific antipsychotics. As a result, product labels and guidelines from various PGx expert groups have p …
Most robust findings from candidate gene and genomewide association studies were reported for associations between polymorphisms in CYP2D …
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.
Ur Rasheed MS, Mishra AK, Singh MP. Ur Rasheed MS, et al. Neurochem Res. 2017 Dec;42(12):3353-3361. doi: 10.1007/s11064-017-2384-8. Epub 2017 Sep 4. Neurochem Res. 2017. PMID: 28871472 Review.
Cytochrome P450 (CYP) 2D6 is one of the most highly active, oxidative and polymorphic enzymes known to metabolize Parkinsonian toxins and clinically established anti-Parkinson's disease (PD) drugs. ...CYP2D6 gene codes for a set of alternate splice …
Cytochrome P450 (CYP) 2D6 is one of the most highly active, oxidative and polymorphic enzymes known to metabolize Parkinsonian …
Cytochrome P450 CYP2D6.
Wolf CR, Smith G. Wolf CR, et al. IARC Sci Publ. 1999;(148):209-29. IARC Sci Publ. 1999. PMID: 10493260 Review.
As CYP2D6 substrates have a wide range of pharmacological functions, any variation in CYP2D6 expression can have profound clinical consequences. ...For example, the PM genotype is particularly rare in Orientals. The inheritance of certain CYP2D6 allelic va …
As CYP2D6 substrates have a wide range of pharmacological functions, any variation in CYP2D6 expression can have profound clin …
Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Daly AK. Daly AK. Adv Pharmacol. 2015;74:85-111. doi: 10.1016/bs.apha.2015.03.001. Epub 2015 May 11. Adv Pharmacol. 2015. PMID: 26233904 Review.
Associations of cytochrome P450 (CYP) polymorphisms with risk of disease development have been reported widely. ...CYP2C isoforms and CYP2J2 contribute to extrahepatic metabolism of arachidonic acid to epoxyeicosanoic acids which have effects in the cardiovas …
Associations of cytochrome P450 (CYP) polymorphisms with risk of disease development have been reported widely. ...CYP2 …
Psychotropic drugs and CYP2D6 in late-life psychiatric and neurological disorders. What do we know?
Seripa D, Lozupone M, Stella E, Paroni G, Bisceglia P, La Montagna M, D'onofrio G, Gravina C, Urbano M, Priore MG, Lamanna A, Daniele A, Bellomo A, Logroscino G, Greco A, Panza F. Seripa D, et al. Expert Opin Drug Saf. 2017 Dec;16(12):1373-1385. doi: 10.1080/14740338.2017.1389891. Epub 2017 Oct 12. Expert Opin Drug Saf. 2017. PMID: 29025271 Review.
Late-life psychiatric and neurological disorders (LLPND) are interesting models to understand the potential role of pharmacogenetics in drug management, since several pharmacological approaches for treating LLPND have proven to be ineffective or deleterious, thus resulting …
Late-life psychiatric and neurological disorders (LLPND) are interesting models to understand the potential role of pharmacogenetics …
Atomoxetine: A Review of Its Pharmacokinetics and Pharmacogenomics Relative to Drug Disposition.
Yu G, Li GF, Markowitz JS. Yu G, et al. J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26. doi: 10.1089/cap.2015.0137. Epub 2016 Feb 9. J Child Adolesc Psychopharmacol. 2016. PMID: 26859445 Free PMC article. Review.
Its metabolism and disposition are fairly complex, and primarily governed by cytochrome P450 (CYP) 2D6 (CYP2D6), whose protein expression varies substantially from person to person, and by race and ethnicity because of genetic polymorphism. ...Further, a summ …
Its metabolism and disposition are fairly complex, and primarily governed by cytochrome P450 (CYP) 2D6 (CYP2D6), whose …
Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
Neafsey P, Ginsberg G, Hattis D, Sonawane B. Neafsey P, et al. J Toxicol Environ Health B Crit Rev. 2009;12(5-6):334-61. doi: 10.1080/10937400903158342. J Toxicol Environ Health B Crit Rev. 2009. PMID: 20183526 Review.
Cytochrome P-450 2D6 (CYP2D6) is involved in the metabolism of many therapeutic drugs even though the enzyme represents a small proportion of the total CYP content of human liver. ...Gene probe studies documented a number of genetic polymorphism …
Cytochrome P-450 2D6 (CYP2D6) is involved in the metabolism of many therapeutic drugs even though the enzyme …
Pharmacogenomics in psychiatry: implications for practice.
Moore TR, Hill AM, Panguluri SK. Moore TR, et al. Recent Pat Biotechnol. 2014;8(2):152-9. doi: 10.2174/1872208309666140904113615. Recent Pat Biotechnol. 2014. PMID: 25185985 Review.
Because of the risks of adverse effects and need for adherence, risk mitigation strategies are being implemented to protect consumers. An understanding of receptor activities, cytochrome P450 2D6 and 2C19 metabolism, overlapping pharmacology, and polymorphic biomark …
Because of the risks of adverse effects and need for adherence, risk mitigation strategies are being implemented to protect consumers. An un …
66 results